Evaluation of the effect of sildenafil on the microvascular blood flow in patients with systemic sclerosis: a randomised, double-blind, placebo-controlled study.
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Roth M, LeClair H, et al. Mycophenolate mofetil and cyclophosphamide improve health-related quality of life in patients with systemic sclerosis who participated in SLS II. Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial. Efficacy and safety of tocilizumab for the treatment of systemic sclerosis: results from a phase 3 randomized controlled trial. Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study.
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Randomized placebo-controlled crossover trial of tadalafil in Raynaud’s phenomenon secondary to systemic sclerosis. Efficacy of tadalafil in secondary Raynaud’s phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial. Intravenous iloprost treatment of Raynaud’s phenomenon and ischemic ulcers secondary to systemic sclerosis.
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Intravenous iloprost infusion in patients with Raynaud phenomenon secondary to systemic sclerosis.
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Combination therapy with rituximab and mycophenolate mofetil in systemic sclerosis. Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis. Interstitial lung disease in systemic sclerosis: data from the spanish scleroderma study group. Severe restrictive lung disease in systemic sclerosis. Causes and risk factors for death 20mg sildenafil in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database.
2.4. Pulmonary hypertension
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2.5. Gastrointestinal disease
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Article highlights.
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2.1. Cutaneous sclerosis
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- Sildenafil 100mg Hexal should not be used with nitrate medications.
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- Use only as directed by a healthcare professional.
Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion.
| Region | Average Cost per Pack | Number of Tablets | Insurance Coverage | Notes |
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| USA | $30 - $50 | 30 | Often covered | Generic options available |
| UK | £15 - £25 | 28 | Partially covered | Prescription needed |
| Germany | €20 - €40 | 30 | Usually covered | Generic versions available |
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| Contraindication | Explanation | Recommended Action |
|---|---|---|
| Use with nitrates | Can cause life-threatening hypotension | Avoid concurrent use |
| Severe cardiovascular disease | Increased risk of adverse effects | Consult doctor before use |
| Hypersensitivity to sildenafil | Allergic reactions possible | Discontinue if occurs |
| Severe liver impairment | Drug clearance reduced | Use with caution or avoid |
The recurrence of digital ulcers in patients with systemic sclerosis after discontinuation of oral treprostinil.
Author information
Treatment algorithms for systemic sclerosis according to experts. Emerging targets of disease-modifying therapy for systemic sclerosis. [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Peoples C, Medsger TA Jr., Lucas M, et al. Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes. [DOI] [PMC free article] [PubMed] [Google Scholar] February;34(1):1–15;v.
Erektile Dysfunktion (ED)
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| Property | Description | Value | Notes |
|---|---|---|---|
| Active ingredient | Sildenafil citrate | - | Main component |
| Mechanism of action | PDE5 inhibitor | - | Enhances blood flow |
| Half-life | Approximately 4 hours | 3-5 hours | Duration of effect |
| Absorption | Rapid, peaks in 30-120 minutes | - | After oral intake |
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Authors and Affiliations
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7.2 An Old Success Story—Aspirin
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- Sildenafil 100mg Hexal is a generic medication for erectile dysfunction.
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Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial.