The safety findings from the Phase 2b clinical study have been published and are available on the DARE to PLAY website.
- The effectiveness of Viagra cream depends on skin absorption.
- It is sometimes promoted as a natural alternative.
- Possible benefits include reduced frequency of side effects.
- Scientific evidence supporting its use is limited.
- Users should be wary of false advertising claims.
- Some formulations may contain unsafe or unregulated ingredients.
- Proper use involves cleaning the application area thoroughly.
- The cream should be applied as per product instructions.
- Do not exceed recommended dosage to avoid irritation.
- Keep out of reach of children and pets.
If you experience difficulty with sexual arousal, including a lack of physical response or reduced genital sensitivity during sexual activity, you may benefit from DARE to PLAY. A conversation with a licensed healthcare provider can help determine whether it is appropriate for you. DARE to PLAY contains the same active ingredient as Viagra®, but it’s formulated specifically for women and applied directly where it’s needed. Unlike an oral pill, DARE to PLAY is a topical cream designed to work locally rather than systemically. Apply the cream with your finger 10 to 15 minutes before sexual activity up to once per day. Slowly squeeze out a length of cream about 2 ½ inches long for one 2-gram dose.
Female Sexual Arousal Disorder and Scream Cream
With DARE to PLAY Sildenafil Cream, you can feel confident in what you’re using – every single time. This is the first clinical study of its kind to demonstrate that this specific topical formulation of sildenafil, DARE to PLAY Sildenafil Cream, can support genital blood flow and arousal in women. Offering a non-hormonal option with a faster onset (10–15 minutes) and fewer side effects than oral medications, it represents a significant breakthrough for female sexual health. Daré’s proprietary formulation of Sildenafil Cream was evaluated in the RESPOND Study, the first-ever randomized, double-blind, placebo-controlled clinical trial for a topical treatment targeting Female Sexual Arousal Disorder (FSAD) submitted to the FDA. This Phase 2b trial included 200 premenopausal women experiencing symptoms of FSAD, such as reduced genital sensation and frustration during intimacy.
Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion
Safety Profile: The side effect profile of DARE to PLAY Sildenafil Cream was similar to placebo (cream without sildenafil added), with no serious safety concerns reported. Study Results:Women using DARE to PLAY Sildenafil Cream experienced the following improvements, as measured by clinically validated and FDA-reviewed endpoints: Reduced feelings of sexual distress and interpersonal difficulties resulting from the sexual difficulties In the Phase 2b trial, after 12 weeks, women who used DARE to PLAY Sildenafil Cream reported statistically significant and clinically meaningful improvements in genital arousal sensation (warmth and tingling) compared to those who used placebo cream. On average, Arousal Sensation scores (measured by a patient-reported questionnaire) increased by over 2 points with DARE to PLAY Sildenafil Cream, compared to almost no change with placebo cream. Women who used DARE to PLAY Sildenafil Cream also showed improvement across other key areas of sexual function, including desire and orgasm. Results shown are from a subset of 65 women in a 12-week clinical trial: 33 women who received Sildenafil Cream and 32 who received Placebo Cream. Lying on your back, apply half the cream on and around the clitoris and the area around the vaginal opening, avoiding areas with hair.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Professional | 100mg | 10 Pills | 44.09€ 41.99€ | |
| Viagra Original | 100mg | 8 Pills | 59.84€ 56.99€ | |
| Viagra Super Active | 100mg | 360 + 30 Pills | 470.93€ 448.50€ | |
| Viagra Professional | 100mg | 30 Pills | 88.92€ 84.69€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Viagra Generic | 25mg | 90 + 6 Pills | 105.03€ 100.03€ | |
| Viagra Generic | 100mg | 20 Pills | 45.58€ 43.41€ | |
| Viagra Professional | 100mg | 90 + 2 Pills | 207.09€ 197.23€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Viagra Original | 100mg | 64 + 4 Pills | 264.15€ 251.57€ | |
| Viagra Professional | 100mg | 360 + 6 Pills | 527.09€ 501.99€ | |
| Viagra Super Active | 100mg | 30 + 6 Pills | 64.09€ 61.04€ | |
| Viagra Original | 100mg | 120 + 8 Pills | 470.39€ 447.99€ | |
| Viagra Super Active | 100mg | 60 + 8 Pills | 116.84€ 111.28€ | |
| Viagra Original | 100mg | 14 + 2 Pills | 89.03€ 84.79€ | |
| Viagra Professional | 100mg | 60 + 2 Pills | 146.74€ 139.75€ | |
| Viagra Original | 100mg | 4 Pills | 40.94€ 38.99€ |
Apply the rest of the cream just inside the vagina, rubbing the cream with a curved finger on the front wall of the vagina. Once applied, do not wipe off any of the cream until after sexual activity.
Introduction: Sexual Health, Gender, and the Visibility Gap
The results were published in the Green Journal (Obstetrics & Gynecology), the official journal of the American College of Obstetricians and Gynecologists (ACOG) and highlighted on ACOG’s podcast The Green Room. Clinical trial results were also featured in The Journal of Sexual Medicine, the official journal of the International Society for the Study of Women’s Sexual Health. DARE to PLAY is the only sildenafil cream for women supported by published, peer-reviewed clinical data. It was studied in clinical trials that used buy female viagra clinically validated and FDA-reviewed endpoints to measure results. The cream is designed with a proprietary drug delivery system that helps sildenafil get into the vaginal and vulvar tissue, where it can act locally to increase blood flow.
Estradiol Vaginal Cream
Other sildenafil creams on the market haven’t been proven to work–they have not been studied, shown to absorb properly or published in peer-reviewed research, and are often compounded without consistent quality standards. DARE to PLAY stands apart because it’s rigorously developed, science-backed, and held to the highest standards of quality and clinical evidence. Sildenafil (the active ingredient in Viagra®) has a long-established safety profile in men. The topical formulation used in DARE to PLAY is designed to work locally (in the tissues that matter for sexual arousal) while minimizing how much of the drug enters the bloodstream. DARE to PLAY has been evaluated in clinical studies and was well tolerated, with no significant safety concerns reported. In the Phase 2b clinical study, women did not use lubricants because the study was specifically designed to evaluate the impact of DARE to PLAY on the genital arousal response. However, there are no concerns about the compatibility of lubricants with the DARE to PLAY formulation. DARE to PLAY has been studied in both pre-and postmenopausal women to evaluate safety, tolerability, and how the drug is absorbed in the body (pharmacokinetics). In these studies, the cream was well tolerated.
- Viagra cream is often used by men seeking a discreet option.
- It is a semi-liquid formulation that enhances intimacy.
- The cream may be combined with other topical agents.
- Its shelf life depends on storage conditions.
- Usually available through online vendors, sometimes unregulated.
- The safety and efficacy of Viagra cream are not FDA-approved.
- Users should consult a healthcare provider before use.
- Possible side effects include skin irritation or headache.
- The dosage can vary depending on the product formulation.
- Use with caution if taking nitrates or other medications.
The Phase 2b clinical study enrolled healthy pre-and perimenopausal women aged 18 to 45 who had a diagnosis of Female Sexual Arousal Disorder (FSAD). Similar to FDA-approved products for Hypoactive Sexual Desire Disorder (HSDD), FSAD trials conducted for FDA review typically focus on either pre-or postmenopausal populations. In the Phase 2b clinical study, approximately one-third of the participants were taking an SSRI. An informal analysis compared women on SSRIs with those who were not and found that both groups showed positive trends in improved arousal sensations. Many vaginal products contain ingredients that can weaken condoms, increasing the risk of breakage. DARE to PLAY was tested using ASTM D7661-10, a standardized method that ensures a product is safe to use with condoms. Based on these tests, DARE to PLAY is compatible with all male condoms except those made of polyurethane.
- Viagra cream is part of a broader category of topical ED treatments.
- It offers an alternative for men who dislike oral medications.
- The product may be flavored or designed to mask medicinal taste.
- It can be used with other sexual enhancement products cautiously.
- Some users prefer creams for their discreet nature.
- Clinical research is ongoing into topical PDE5 inhibitors.
- Side effects may include skin rash or allergic reaction.
- Realistic expectations are important for satisfaction.
- Price varies based on brand, formulation, and availability.
- Always purchase from reputable sources to ensure quality.
In the Phase 2b clinical study, women were allowed to use DARE to PLAY during oral sex, and it was well tolerated with no significant safety concerns.
All your sexual health questions answered
Talk with your provider to see if DARE to PLAY is right for you. Bring this prescribing guide to your visit: Right now, you can get a prescription for DARE to PLAY — even though you cannot place an order yet. Sildenafil (the active ingredient in Viagra®) has been proven for decades to increase blood flow. DARE to PLAY Sildenafil Cream uses the same trusted ingredient in a targeted topical formula designed for the unique anatomy of the female genitals. It works by helping blood vessels in the clitoris and vulva relax and open, allowing increased blood flow – resulting in: Warmth, swelling, tingling/throbbing, and sensitivity in the genital area It has been shown to increase blood flow within 10-15 minutes after application.
Is topical sildenafil cream FDA-approved for women?
We also got busy with a full clinical study of 200 women experiencing symptoms of FSAD. Getting powerful ingredients like sildenafil through the skin isn’t easy – most drugs carry an electrical charge, and the skin’s outer layer (called the stratum corneum) is built to keep them out. That’s where DermaFlux™, a cutting-edge topical drug delivery system, comes in. This advanced cream technology helps deliver sildenafil deep into the tissues that matter for sexual arousal. The cream uses special salts—tri-sodium citrate and potassium chloride—to helppush the active ingredient through theskin’s toughest layer. Prior to the Phase 2b clinical study, DARE to PLAY was also tested in a preclinical study to assess its effects on the oral mucosa. These tests showed that daily exposure for 28 days did not cause irritation inside the mouth.
| Form | Average Price | Dosage per unit | Advantages | Disadvantages |
|---|---|---|---|---|
| Cream | $25 per tube | 2.5g | Localized effect, quick onset | May cause skin irritation |
| Tablet | $20 per pill | 50mg | Easy to dose, well-studied | Systemic effects, longer onset |
| Injectable | $50 per injection | Variable | Rapid effect | Invasive, requires health professional |
The DARE to PLAY formulation does contain a proprietary combination of salts that support the absorption of sildenafil into the tissue. As a result, you may notice a mildly salty taste.
| Brand Name | Manufacturer | Price (per tube) | Customer Ratings |
|---|---|---|---|
| ViraCream | PharmaHealth Co. | $25 | 4.5/5 |
| ErectaGel | Medico Pharmaceuticals | $30 | 4.2/5 |
| LibidoBoost | BioWell Inc. | $20 | 4.0/5 |
DARE to PLAY can be used in both situations! In the Phase 2b clinical study, about 20% of sexual events were solo, and women reported that these experiences were often more satisfying than partnered events. Partnered events sometimes occurred under less-than-ideal conditions, like limited time or distractions, which can affect pleasure. DARE to PLAY is designed to complement, not replace, other approaches. It is a pharmacologic option focused on improving genital blood flow and physical responsiveness. Women often benefit most from a multimodal approach.
- Viagra cream might be preferred for its quick onset.
- It allows for discreet use without oral ingestion.
- Not advisable for use with alcohol or recreational drugs.
- Check for allergies to components before use.
- Effects typically last for around 1-2 hours.
- It should be applied to clean, dry skin.
- Enhancers or additional lubricants may improve effectiveness.
- It is advisable to consult a doctor concerning underlying health issues.
- Read and follow all instructions carefully.
- Be aware of potential counterfeit or substandard products.
DARE to PLAY is designed to improve physical arousal by increasing genital blood flow. Many women find that enhancing physical responsiveness can also help restore desire and confidence. In the Phase 2b clinical study, women with low desire due to diminished physical arousal sensations experienced improved desire following use of DARE to PLAY.
HOW TO GET YOUR PRESCRIPTION
Normally, drugs can stick to the skin’ssurface due to hydrogen bonding. Thehigh salt content in this cream helpsprevent that stickiness, allowingsildenafil to penetrate deeper into thetissue. The cream’s design includes bothwater-loving (hydrophilic) and oil-loving (hydrophobic) regions. This uniquestructure helps the cream interact withdifferent skin layers, ensuring the druggets where it needs to go. The cream uses special salts—tri-sodium citrate and potassiumchloride—to help push the activeingredient through the skin’stoughest layer.
Formulated to work within 30 minutes
Normally, drugs can stick to theskin’s surface due to hydrogenbonding. The high salt content inthis cream helps prevent thatstickiness, allowing sildenafil topenetrate deeper into the tissue. Thisunique structure helps the creaminteract with different skin layers,ensuring the drug gets where itneeds to go. May not penetrate into the epithelial tissue When it comes to your body and your health, consistency and safety aren’t optional – they are essential. You deserve a product that has been clinically studied, carefully formulated, and made to the highest safety and quality standards.